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Skip Navigation LinksAbout-CmAbs

​​​Next generation of antibody-based therapeutics (CmAbs)
ImmunGene's technology empowers monoclonal antibodies targeted to tumor cells by fusing them to immune effector molecule(s) e.g. cytokine, chemokine and co-stimulatory molecule(s), thereby combining the specificity of antibodies with the potent anti-tumor effects of immune effector molecule. Our antibody-fusion proteins are designed to be stable in the bloodstream and efficiently target cancer cells. This approach allows sparing non-targeted cells and thus reducing many of the toxic effects of traditional immune effector molecules while enhancing the antitumor activity of the antibody. Our lead antibody-fusion molecule uses IFNa effector cytokine. 

Stand alone targeted cytotoxic therapy and optimized immune cell mediated attack against tumor killing.

ANTIBODY-FUSION MOLECULE MECHANISM OF ACTION 

Antibody-Fusion Mechanism of Action

Quick fact about CmAbs

♦ CmAb - Antibody fused with immune effector molecule   
♦ CmAb MW ranges 160-180 kDa compared to ~150 kDa of mAb   
♦ CmAb is genetically engineered molecule 
    - no chemical conjugation 
    - homogenous single step production   
♦ Cytokine/chemokine fusion does NOT create steric hindrance with Fc and antigen binding 
    - intact ADCC and CDC functions   
♦ CmAb are manufactured in mAb producing commercial cell lines   
♦ CmAb platform offers a unique competitive advantage against unconjugated and conjugated antibodies in a highly competitive market

♦ Potentially low COGS